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Compound Detail

CHEMBL4062705

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CC(C)(Oc1ccc(Cl)cc1)C(=O)Nc1ncc([N+](=O)[O-])s1

Basic Information

ChEMBL ID CHEMBL4062705
Phase Preclinical
Structure Type MOL
InChI Key YEFSQASFGWYJOU-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

341.8
MW (Da)
3.50
ALogP
6
HBA
1
HBD
94.4
PSA (Ų)
0.66
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H12ClN3O4S
MW 341.78
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -1.97

Activity Summary

IC50 5 meas. best 7.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trichomonas vaginalis
CHEMBL612884
IC50 7.5 7.5 32.0 1
Giardia intestinalis
CHEMBL612652
IC50 6.76 6.76 172.0 1
Leishmania amazonensis
CHEMBL612877
IC50 5.46 5.46 3430.0 1
Trypanosoma cruzi
CHEMBL368
IC50 4.91 4.91 12220.0 1
Leishmania mexicana
CHEMBL612880
IC50 4.78 4.78 16590.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28645659 10.1016/j.bmcl.2017.05.071 Giardia intestinalis 5
28645659 10.1016/j.bmcl.2017.05.071 Trichomonas vaginalis 3
28645659 10.1016/j.bmcl.2017.05.071 Unchecked 3
28645659 10.1016/j.bmcl.2017.05.071 Trypanosoma cruzi 2
28645659 10.1016/j.bmcl.2017.05.071 Leishmania amazonensis 1
28645659 10.1016/j.bmcl.2017.05.071 Leishmania mexicana 1
28645659 10.1016/j.bmcl.2017.05.071 Vero 1

Data from ChEMBL 36 via Core Engine