Assay Detail
Functional
CHEMBL4056313
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Antiprotozoal activity against Leishmania mexicana MHOM/MX/ISETGS incubated for 72 hrs by Neubauer chamber based cell counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania mexicana |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.09 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.69 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.51 |
| CHEMBL4100836 | — | — | 1 | 5.21 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 5.21 |
| CHEMBL4084390 | — | — | 1 | 5.17 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.88 |
| CHEMBL4062705 | — | — | 1 | 4.78 |
| CHEMBL4071348 | — | — | 1 | 4.77 |
| CHEMBL4092145 | — | — | 1 | 4.59 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | - |
| CHEMBL4065457 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4100836 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL4084390 | — | IC50 | = | 6770.0 | nM | 5.17 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 13320.0 | nM | 4.88 |
| CHEMBL4062705 | — | IC50 | = | 16590.0 | nM | 4.78 |
| CHEMBL4071348 | — | IC50 | = | 17140.0 | nM | 4.77 |
| CHEMBL4092145 | — | IC50 | = | 25540.0 | nM | 4.59 |
| CHEMBL137 | METRONIDAZOLE | IC50 | > | 50000.0 | nM | - |
| CHEMBL4065457 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | > | 50000.0 | nM | - |