Compound Detail
CHEMBL4205072
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Basic Information
| ChEMBL ID | CHEMBL4205072 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGEVLFLWRHGXHS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
275.4
MW (Da)
3.08
ALogP
3
HBA
0
HBD
46.6
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase CHEMBL2034805 | IC50 | 6.36 | 6.36 | 440.0 | 1 |
| N-acylethanolamine-hydrolyzing acid amidase CHEMBL4349 | IC50 | 6.36 | 6.36 | 440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase | IC50 | = | 440.0 | nM | 6.36 | Inhibition of rat NAAA expressed in HEK293 cells using heptadecenoylethanolamide... | 28802121 |
| N-acylethanolamine-hydrolyzing acid amidase | IC50 | = | 440.0 | nM | 6.36 | Determining Endocannabinoid Hydrolase Activity: In the Experimental example, end... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28802121 | 10.1016/j.ejmech.2017.08.004 | N-acylethanolamine-hydrolyzing acid amidase | 1 |
Data from ChEMBL 36 via Core Engine