Compound Detail
CHEMBL4247121
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Basic Information
| ChEMBL ID | CHEMBL4247121 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OMONHEJVJYRTAT-UHFFFAOYSA-N |
2
Targets
6
Activities
2
Assay Types
2
PK Parameters
4
Publications
0
Known Names
Molecular Properties
460.6
MW (Da)
5.04
ALogP
9
HBA
2
HBD
102.7
PSA (Ų)
0.40
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.4
Ki 2 meas. best 9.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity protein kinase TTK CHEMBL3983 | Ki | 9.92 | 9.92 | 0.1 | 1 |
| Dual specificity protein kinase TTK CHEMBL3983 | IC50 | 8.4 | 7.9333 | 4.0 | 3 |
| CDK2/Cyclin A2 CHEMBL3038469 | Ki | 6.33 | 6.33 | 470.0 | 1 |
| CDK2/Cyclin A2 CHEMBL3038469 | IC50 | 6.03 | 6.03 | 940.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 20.4 | mL.min-1.g-1 | Homo sapiens |
| CL | 32.9 | mL.min-1.g-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity protein kinase TTK | Ki | = | 0.12 | nM | 9.92 | Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculo... | 30199249 |
| Dual specificity protein kinase TTK | IC50 | = | 4.0 | nM | 8.4 | Measurement of Inhibition of MPS1 Kinase: The enzyme reaction (total volume 10 μ... | - |
| Dual specificity protein kinase TTK | IC50 | = | 12.0 | nM | 7.92 | Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculo... | 30199249 |
| Dual specificity protein kinase TTK | IC50 | = | 33.0 | nM | 7.48 | Inhibition of MPS1 autophosphorylation at Thr33/Ser37 in human HCT116 cells afte... | 30199249 |
| CDK2/Cyclin A2 | Ki | = | 470.0 | nM | 6.33 | Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in ... | 30199249 |
| CDK2/Cyclin A2 | IC50 | = | 940.0 | nM | 6.03 | Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in ... | 30199249 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30199249 | 10.1021/acs.jmedchem.8b00690 | Dual specificity protein kinase TTK | 3 |
| 30199249 | 10.1021/acs.jmedchem.8b00690 | CDK2/Cyclin A2 | 2 |
| 30199249 | 10.1021/acs.jmedchem.8b00690 | ADMET | 2 |
| 30199249 | 10.1021/acs.jmedchem.8b00690 | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine