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Compound Detail

CHEMBL429797

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CCCCCCC(C)(C)c1cc(O)c2c(c1)oc(=O)c1ccc(O)cc12

Basic Information

ChEMBL ID CHEMBL429797
Phase Preclinical
Structure Type MOL
InChI Key BWKBVEVEQOCSCF-UHFFFAOYSA-N
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

354.4
MW (Da)
5.61
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.34
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H26O4
MW 354.45
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness 0.88

Activity Summary

Ki 5 meas. best 9.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
Ki 9.09 9.09 0.8 2
Cannabinoid receptor 2
CHEMBL5373
Ki 9.09 9.09 0.8 1
Cannabinoid receptor 1
CHEMBL218
Ki 6.4 6.4 400.0 1
Cannabinoid receptor 1
CHEMBL3571
Ki 6.4 6.4 400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18038967 10.1021/jm070441u Cannabinoid receptor 2 3
18038967 10.1021/jm070441u Rattus norvegicus 2
18038967 10.1021/jm070441u Cannabinoid receptor 1 1
18038967 10.1021/jm070441u Unchecked 1
19143566 10.1021/jm801044g Cannabinoid receptor 1 1
19143566 10.1021/jm801044g Cannabinoid receptor 2 1
19143566 10.1021/jm801044g Unchecked 1
27494166 10.1016/j.ejmech.2016.07.057 Cannabinoid receptor 2 1

Data from ChEMBL 36 via Core Engine