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Compound Detail

CHEMBL439122

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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL439122
Phase Preclinical
Structure Type MOL
InChI Key QHUWIYRYNYUDLJ-CDTCBKJLSA-N
4
Targets
10
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

2221.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C102H161N31O25
MW 2221.60

Activity Summary

Ki 10 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuropeptide Y receptor type 2
CHEMBL4018
 Ki 9.0 8.2633 1.0 3
Neuropeptide Y receptor type 4
CHEMBL4877
 Ki 6.7 6.7 199.5 2
Neuropeptide Y receptor type 1
CHEMBL4777
 Ki 6.58 6.46 261.0 3
Neuropeptide Y receptor type 5
CHEMBL4561
 Ki 5.9 5.895 1258.9 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Neuropeptide Y receptor type 2 Ki = 1.0 nM 9.0 Tested against neuropeptide Y2 receptors using SK-N-BE2 human neuroblastoma cell... 8426366
Neuropeptide Y receptor type 2 Ki = 12.59 nM 7.9 Displacement of [125I]-PYY(1 to 36 residues) from human Y2R expressed in CHO cel... 30399314
Neuropeptide Y receptor type 2 Ki = 13.0 nM 7.89 Displacement of [125I]-PYY(1 to 36 residues) from human Y2R expressed in CHO cel... 30399314
Neuropeptide Y receptor type 4 Ki = 200.0 nM 6.7 Displacement of [125I]-PP from human Y4R expressed in CHO-K1 cell membranes afte... 30399314
Neuropeptide Y receptor type 4 Ki = 199.53 nM 6.7 Displacement of [125I]-PP from human Y4R expressed in CHO-K1 cell membranes afte... 30399314
Neuropeptide Y receptor type 1 Ki = 261.0 nM 6.58 Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells 8426366
Neuropeptide Y receptor type 1 Ki = 400.0 nM 6.4 Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 ... 30399314
Neuropeptide Y receptor type 1 Ki = 398.11 nM 6.4 Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 ... 30399314
Neuropeptide Y receptor type 5 Ki = 1258.93 nM 5.9 Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 ... 30399314
Neuropeptide Y receptor type 5 Ki = 1300.0 nM 5.89 Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 ... 30399314

Literature References

PubMed DOI Target Context # Activities
30399314 10.1021/acs.jmedchem.8b01046 Unchecked 3
30399314 10.1021/acs.jmedchem.8b01046 Neuropeptide Y receptor type 1 2
30399314 10.1021/acs.jmedchem.8b01046 Neuropeptide Y receptor type 2 2
30399314 10.1021/acs.jmedchem.8b01046 Neuropeptide Y receptor type 4 2
30399314 10.1021/acs.jmedchem.8b01046 Neuropeptide Y receptor type 5 2
8426366 10.1021/jm00055a010 Neuropeptide Y receptor type 1 1
8426366 10.1021/jm00055a010 Neuropeptide Y receptor type 2 1

Data from ChEMBL 36 via Core Engine