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Compound Detail

CHEMBL442333

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c1ccc(Nc2[nH]c3ccccc3c3nc(C4CCCC4)nc2-3)cc1

Basic Information

ChEMBL ID CHEMBL442333
Phase Preclinical
Structure Type MOL
InChI Key SLVRVRBSUMQWAC-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

328.4
MW (Da)
5.46
ALogP
3
HBA
2
HBD
53.6
PSA (Ų)
0.52
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H20N4
MW 328.42
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.64

Activity Summary

Ki 5 meas. best 7.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL4975
Ki 7.64 7.64 23.0 1
Adenosine receptor A1
CHEMBL318
Ki 6.64 6.64 230.0 1
Adenosine receptor A3
CHEMBL256
Ki 6.11 6.11 786.0 1
Adenosine receptor A2a
CHEMBL251
Ki 5.5 5.5 3150.0 1
Adenosine receptor A1
CHEMBL226
Ki 5.47 5.47 3420.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16722654 10.1021/jm060086s Adenosine receptor A3 4
2002461 10.1021/jm00107a046 Adenosine receptor A1 2
2002461 10.1021/jm00107a046 Adenosine A2 receptor 1
2002461 10.1021/jm00107a046 Adenosine receptors; A1 & A2 1
16722654 10.1021/jm060086s Adenosine receptor A2a 1
16722654 10.1021/jm060086s Adenosine receptor A2b 1
16722654 10.1021/jm060086s Adenosine receptor A1 1

Data from ChEMBL 36 via Core Engine