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Compound Detail

CHEMBL4443911

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Cn1cc(C(F)(F)F)nc1-c1ccc(OC[C@@H](O)CNCCOc2ccc(OCCSSCCN)c(C(N)=O)c2)cc1

Basic Information

ChEMBL ID CHEMBL4443911
Phase Preclinical
Structure Type MOL
InChI Key VFIGQPOLOHYAJG-IBGZPJMESA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

629.7
MW (Da)
3.33
ALogP
11
HBA
4
HBD
146.9
PSA (Ų)
0.12
QED
2
Ro5 Violations
18
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H34F3N5O5S2
MW 629.73
Aromatic Rings 3
Heavy Atoms 42
NP-Likeness -0.78

Activity Summary

Ki 2 meas. best 7.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL3440
Ki 7.31 7.31 49.0 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 5.7 5.7 2000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31151791 10.1016/j.bmc.2019.05.034 Unchecked 7
31151791 10.1016/j.bmc.2019.05.034 Beta-2 adrenergic receptor 1
31151791 10.1016/j.bmc.2019.05.034 Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine