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Compound Detail

CHEMBL4455542

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Cc1ccc(COc2nc(C)c(C)n3cc([N+](=O)[O-])nc23)cc1

Basic Information

ChEMBL ID CHEMBL4455542
Phase Preclinical
Structure Type MOL
InChI Key OMBZVJBKNOEOFT-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

312.3
MW (Da)
3.14
ALogP
6
HBA
0
HBD
82.6
PSA (Ų)
0.55
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H16N4O3
MW 312.33
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -1.31

Activity Summary

IC50 4 meas. best 5.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei brucei
CHEMBL612851
IC50 5.66 5.63 2200.0 2
Giardia intestinalis
CHEMBL612652
IC50 5.24 5.22 5800.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30468386 10.1021/acs.jmedchem.8b01578 Giardia intestinalis 2
30468386 10.1021/acs.jmedchem.8b01578 Entamoeba histolytica 2
30468386 10.1021/acs.jmedchem.8b01578 Mycobacterium tuberculosis 2
30468386 10.1021/acs.jmedchem.8b01578 Trypanosoma brucei brucei 2

Data from ChEMBL 36 via Core Engine