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Compound Detail

CHEMBL4456301

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COc1cc(CCNC[C@H](O)COc2cccc3ccccc23)ccc1OCCCSSCCN

Basic Information

ChEMBL ID CHEMBL4456301
Phase Preclinical
Structure Type MOL
InChI Key QJSQCJQXYAAGGS-QHCPKHFHSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

516.7
MW (Da)
4.53
ALogP
8
HBA
3
HBD
86.0
PSA (Ų)
0.18
QED
1
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H36N2O4S2
MW 516.73
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.34

Activity Summary

Ki 3 meas. best 10.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 10.14 10.14 0.1 1
Unchecked
CHEMBL612545
Ki 9.74 9.74 0.2 1
Beta-1 adrenergic receptor
CHEMBL3440
Ki 8.96 8.96 1.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31151791 10.1016/j.bmc.2019.05.034 Unchecked 5
31151791 10.1016/j.bmc.2019.05.034 Beta-2 adrenergic receptor 1
31151791 10.1016/j.bmc.2019.05.034 Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine