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Compound Detail

CHEMBL4456505

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COCCc1ccc(OC[C@H](O)CNCCc2ccc(OCCSSCCN)c(OC)c2)cc1

Basic Information

ChEMBL ID CHEMBL4456505
Phase Preclinical
Structure Type MOL
InChI Key DMFJWPHVIMGYIO-JOCHJYFZSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

510.7
MW (Da)
3.18
ALogP
9
HBA
3
HBD
95.2
PSA (Ų)
0.19
QED
1
Ro5 Violations
19
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H38N2O5S2
MW 510.72
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.27

Activity Summary

Ki 3 meas. best 7.18

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 7.18 7.18 66.0 1
Beta-1 adrenergic receptor
CHEMBL3440
Ki 6.13 6.13 740.0 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 5.89 5.89 1300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31151791 10.1016/j.bmc.2019.05.034 Unchecked 3
31151791 10.1016/j.bmc.2019.05.034 Beta-2 adrenergic receptor 1
31151791 10.1016/j.bmc.2019.05.034 Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine