Compound Detail
CHEMBL4460335
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Basic Information
| ChEMBL ID | CHEMBL4460335 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HNKBEWDWWSYVSP-UHFFFAOYSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
376.3
MW (Da)
2.69
ALogP
4
HBA
2
HBD
79.8
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.66
Ki 1 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | Ki | 7.89 | 7.89 | 13.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | IC50 | 7.66 | 7.66 | 22.0 | 1 |
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | IC50 | 7.66 | 7.66 | 22.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 7.66 | 7.66 | 22.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | Ki | = | 13.0 | nM | 7.89 | Displacement of [3H]Ro25-6981 from rat GluN2B receptor | 30891123 |
| Glutamate NMDA receptor; GRIN1/GRIN2B | IC50 | = | 22.0 | nM | 7.66 | Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in C... | 30891123 |
| Unchecked | IC50 | = | 22.0 | nM | 7.66 | Negative allosteric modulation of human GluN1a/GluN2B receptor expressed in CHO ... | 32787105 |
| Glutamate receptor ionotropic, NMDA 2B | IC50 | = | 22.0 | nM | 7.66 | Standard cell-based calcium flux assay: NMDA receptors are ion channels that are... | - |
| Glutamate NMDA receptor; GRIN1/GRIN2B | IC50 | = | 22.0 | nM | 7.66 | Biological Assay (standard): NMDA receptors are ion channels that are highly per... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32787105 | 10.1021/acs.jmedchem.9b02113 | Unchecked | 4 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | No relevant target | 2 |
| 32787105 | 10.1021/acs.jmedchem.9b02113 | No relevant target | 2 |
| 32787105 | 10.1021/acs.jmedchem.9b02113 | ADMET | 2 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Glutamate receptor ionotropic, NMDA 2B | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Ionotropic glutamate receptor NMDA 1/2D | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Ionotropic glutamate receptor NMDA 1/2C | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Glutamate NMDA receptor; GRIN1/GRIN2A | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Glutamate NMDA receptor; GRIN1/GRIN2B | 1 |
| 32787105 | 10.1021/acs.jmedchem.9b02113 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine