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Compound Detail

CHEMBL4474388

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Cc1[nH]c(=O)c2nc([N+](=O)[O-])cn2c1C

Basic Information

ChEMBL ID CHEMBL4474388
Phase Preclinical
Structure Type MOL
InChI Key GNCWMKMAAOQMPJ-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

208.2
MW (Da)
0.55
ALogP
5
HBA
1
HBD
93.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H8N4O3
MW 208.18
Aromatic Rings 2
Heavy Atoms 15
NP-Likeness -1.43

Activity Summary

IC50 4 meas. best 5.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei brucei
CHEMBL612851
IC50 5.6 5.59 2511.9 2
Giardia intestinalis
CHEMBL612652
IC50 4.3 4.3 50000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30468386 10.1021/acs.jmedchem.8b01578 Giardia intestinalis 2
30468386 10.1021/acs.jmedchem.8b01578 Entamoeba histolytica 2
30468386 10.1021/acs.jmedchem.8b01578 Mycobacterium tuberculosis 2
30468386 10.1021/acs.jmedchem.8b01578 Trypanosoma brucei brucei 2
- 10.6019/CHEMBL4513134 HEK293 1

Data from ChEMBL 36 via Core Engine