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Compound Detail

CHEMBL4530091

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Clc1cccc(CNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)c1

Basic Information

ChEMBL ID CHEMBL4530091
Phase Preclinical
Structure Type MOL
InChI Key YLUPQKCHATVQQM-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

400.3
MW (Da)
4.73
ALogP
5
HBA
2
HBD
66.5
PSA (Ų)
0.49
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H11Cl2N5S
MW 400.29
Aromatic Rings 4
Heavy Atoms 26
NP-Likeness -1.17

Activity Summary

Ki 4 meas. best 6.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 6.89 6.89 128.0 1
Sigma intracellular receptor 2
CHEMBL4105864
Ki 6.05 6.05 900.0 1
Alpha-2B adrenergic receptor
CHEMBL1942
Ki 5.76 5.76 1720.0 1
Adenosine receptor A1
CHEMBL226
Ki 5.57 5.57 2710.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30568760 10.1039/C8MD00317C Alpha-2B adrenergic receptor 1
30568760 10.1039/C8MD00317C Adenosine receptor A3 1
30568760 10.1039/C8MD00317C Adenosine receptor A2a 1
30568760 10.1039/C8MD00317C Adenosine receptor A1 1
30568760 10.1039/C8MD00317C Sigma intracellular receptor 2 1

Data from ChEMBL 36 via Core Engine