Compound Detail
CHEMBL453038
NORARMEPAVINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL453038 |
| Name | NORARMEPAVINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NKBBUUNAVOMVER-INIZCTEOSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
299.4
MW (Da)
2.84
ALogP
4
HBA
2
HBD
50.7
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.43
EC50 1 meas. best 4.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 4.63 | 4.63 | 23380.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 4.43 | 4.43 | 37000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.06 | 4.06 | 87029.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 23380.0 | nM | 4.63 | PUBCHEM_BIOASSAY: A cytotoxicity screen of small molecule inhibitors of the PhoP... | - |
| Sodium-dependent dopamine transporter | IC50 | = | 37000.0 | nM | 4.43 | Inhibition of dopamine transporter-mediated [3H]dopamine uptake in Wistar rat st... | 8676127 |
| Unchecked | IC50 | = | 87029.0 | nM | 4.06 | PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8778245 | 10.1021/np960354x | Platelet | 4 |
| 8778245 | 10.1021/np960354x | Aorta | 3 |
| 8676127 | 10.1021/np50124a001 | Unchecked | 2 |
| 8676127 | 10.1021/np50124a001 | Sodium-dependent dopamine transporter | 1 |
Data from ChEMBL 36 via Core Engine