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Compound Detail

CHEMBL4537221

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COc1cc(CCNC[C@H](O)COc2cccc3ccccc23)ccc1OCCSSCCN

Basic Information

ChEMBL ID CHEMBL4537221
Phase Preclinical
Structure Type MOL
InChI Key ZBAVHTZBLFYIAR-QFIPXVFZSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

502.7
MW (Da)
4.14
ALogP
8
HBA
3
HBD
86.0
PSA (Ų)
0.20
QED
1
Ro5 Violations
16
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H34N2O4S2
MW 502.70
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.34

Activity Summary

Ki 3 meas. best 10.08

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 10.08 10.08 0.1 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 9.8 9.8 0.2 1
Beta-1 adrenergic receptor
CHEMBL3440
Ki 9.31 9.31 0.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31151791 10.1016/j.bmc.2019.05.034 Unchecked 5
31151791 10.1016/j.bmc.2019.05.034 Beta-1 adrenergic receptor 1
31151791 10.1016/j.bmc.2019.05.034 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine