Compound Detail
CHEMBL4576280
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C[C@@H]1CN(S(=O)(=O)c2cc(NC(=O)CN3C(=O)NC(C)(C4CC4)C3=O)ccc2Br)C[C@H]1C
Basic Information
| ChEMBL ID | CHEMBL4576280 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KWKAHJNKXUKKKE-AZWPRIFCSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
527.4
MW (Da)
2.38
ALogP
5
HBA
2
HBD
115.9
PSA (Ų)
0.55
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ATPase family AAA domain-containing protein 2 CHEMBL2150837 | IC50 | 7.6 | 7.6 | 25.1 | 1 |
| Chromatin remodeling regulator CECR2 CHEMBL3108639 | IC50 | 6.9 | 6.9 | 125.9 | 1 |
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 4.4 | 4.4 | 39810.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ATPase family AAA domain-containing protein 2 | IC50 | = | 25.12 | nM | 7.6 | Displacement of Alexa Fluor 488-labeled ligand from FLAG-6His-Tev-fused ATAD2 (9... | 32321240 |
| Chromatin remodeling regulator CECR2 | IC50 | = | 125.89 | nM | 6.9 | Displacement of Alexa Fluor 647-labeled GSK tracer from FLAG-6His-Tev-fused CECR... | 32321240 |
| Bromodomain-containing protein 4 | IC50 | = | 39810.72 | nM | 4.4 | Displacement of Alexa Fluor 647-labeled ligand from BRD4 BD1 Y390A mutant (1 to ... | 32321240 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32321240 | 10.1021/acs.jmedchem.0c00021 | No relevant target | 2 |
| 32321240 | 10.1021/acs.jmedchem.0c00021 | ATPase family AAA domain-containing protein 2 | 1 |
| 32321240 | 10.1021/acs.jmedchem.0c00021 | Chromatin remodeling regulator CECR2 | 1 |
| 32321240 | 10.1021/acs.jmedchem.0c00021 | Bromodomain-containing protein 4 | 1 |
| 32321240 | 10.1021/acs.jmedchem.0c00021 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine