Compound Detail
CHEMBL4776082
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Basic Information
| ChEMBL ID | CHEMBL4776082 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OJVYQBCUCNUOGS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
460.5
MW (Da)
2.70
ALogP
9
HBA
2
HBD
138.1
PSA (Ų)
0.41
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3839 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Huh-7 CHEMBL614039 | IC50 | 5.69 | 5.69 | 2056.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphoryl... | 32930584 |
| Huh-7 | IC50 | = | 2056.0 | nM | 5.69 | Antiproliferative activity against human HuH7 cells assessed as reduction in cel... | 32930584 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32930584 | 10.1021/acs.jmedchem.0c01019 | ADMET | 4 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Huh-7 | 1 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Fibroblast growth factor receptor 4 | 1 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine