Assay Detail
Functional
CHEMBL4723293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.87 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3973674 | — | — | 1 | 7.92 |
| CHEMBL4796410 | — | — | 1 | 7.68 |
| CHEMBL3968334 | — | — | 1 | 7.60 |
| CHEMBL4284069 | — | — | 1 | 7.58 |
| CHEMBL4742811 | — | — | 1 | 7.57 |
| CHEMBL3983290 | — | — | 1 | 7.39 |
| CHEMBL4745780 | — | — | 1 | 7.33 |
| CHEMBL3951479 | — | — | 1 | 7.28 |
| CHEMBL3912070 | — | — | 1 | 7.28 |
| CHEMBL3946444 | — | — | 1 | 7.17 |
| CHEMBL3972276 | — | — | 1 | 7.14 |
| CHEMBL1852688 | INFIGRATINIB | 4.0 | 1 | 7.10 |
| CHEMBL4784921 | — | — | 1 | 7.05 |
| CHEMBL3904499 | — | — | 1 | 6.97 |
| CHEMBL4294665 | — | — | 1 | 6.87 |
| CHEMBL4759211 | — | — | 1 | 6.85 |
| CHEMBL4784243 | — | — | 1 | 6.75 |
| CHEMBL4756889 | — | — | 1 | 6.75 |
| CHEMBL4764394 | — | — | 1 | 6.75 |
| CHEMBL3950552 | — | — | 1 | 6.71 |
| CHEMBL4279514 | — | — | 1 | 6.62 |
| CHEMBL3916036 | — | — | 1 | 6.59 |
| CHEMBL3904341 | — | — | 1 | 6.47 |
| CHEMBL3966721 | — | — | 1 | 6.41 |
| CHEMBL4106685 | — | — | 1 | 6.33 |
| CHEMBL4758832 | — | — | 1 | 6.22 |
| CHEMBL3925900 | — | — | 1 | 6.18 |
| CHEMBL3920470 | — | — | 1 | 5.96 |
| CHEMBL3964830 | — | — | 1 | 5.79 |
| CHEMBL4776082 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3973674 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4796410 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3968334 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4284069 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4742811 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3983290 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4745780 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3951479 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3912070 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3946444 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3972276 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1852688 | INFIGRATINIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4784921 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3904499 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4294665 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4759211 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4784243 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4756889 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4764394 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3950552 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4279514 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL3916036 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL3904341 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3966721 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL4106685 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL4758832 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL3925900 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL3920470 | — | IC50 | = | 1092.0 | nM | 5.96 |
| CHEMBL3964830 | — | IC50 | = | 1635.0 | nM | 5.79 |
| CHEMBL4776082 | — | IC50 | = | 2056.0 | nM | 5.69 |
| CHEMBL4750281 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4277111 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3969343 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3929437 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3908044 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3954670 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3911617 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4279848 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4287768 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3971213 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3977760 | — | IC50 | > | 3000.0 | nM | - |