Compound Detail
CHEMBL5095230
ATUZAGINSTAT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL5095230 |
| Name | ATUZAGINSTAT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | OLIMBXKACVCIMM-HNNXBMFYSA-N |
6
Targets
15
Activities
1
Assay Types
0
PK Parameters
0
Publications
3
Known Names
1
Indications
Molecular Properties
386.4
MW (Da)
2.86
ALogP
4
HBA
2
HBD
81.4
PSA (Ų)
0.48
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Alzheimer Disease
Activity Summary
IC50 15 meas. best 6.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cathepsin K CHEMBL268 | IC50 | 6.93 | 6.8767 | 117.0 | 3 |
| Cathepsin B CHEMBL4072 | IC50 | 6.42 | 6.42 | 380.0 | 3 |
| Pro-cathepsin H CHEMBL2225 | IC50 | 6.25 | 6.25 | 560.0 | 3 |
| Procathepsin L CHEMBL3837 | IC50 | 5.33 | 5.33 | 4680.0 | 3 |
| Cathepsin F CHEMBL2517 | IC50 | 5.21 | 5.21 | 6100.0 | 2 |
| Cathepsin S CHEMBL2954 | IC50 | 4.53 | 4.53 | 29470.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine