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Compound Detail

CHEMBL5172738

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C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O

Basic Information

ChEMBL ID CHEMBL5172738
Phase Preclinical
Structure Type MOL
InChI Key HRTHPANNFOMYJE-LPRGXNBOSA-N
4
Targets
7
Activities
3
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

2230.6
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C104H136N34O19S2
MW 2230.59

Activity Summary

EC50 3 meas. best 10.09
Ki 3 meas. best 8.75
IC50 1 meas. best 7.63

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Melanocyte-stimulating hormone receptor
CHEMBL3795
EC50 10.09 10.09 0.1 1
Melanocortin receptor 3
CHEMBL4644
EC50 9.8 9.8 0.2 1
Melanocyte-stimulating hormone receptor
CHEMBL3795
Ki 8.75 8.75 1.8 1
Melanocortin receptor 4
CHEMBL259
EC50 8.66 8.66 2.2 1
Melanocortin receptor 3
CHEMBL4644
Ki 7.78 7.78 16.6 1
Melanocortin receptor 5
CHEMBL4608
IC50 7.63 7.63 23.4 1
Melanocortin receptor 4
CHEMBL259
Ki 7.21 7.21 61.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36167503 10.1021/acs.jmedchem.2c00793 Unchecked 4
36167503 10.1021/acs.jmedchem.2c00793 Melanocyte-stimulating hormone receptor 2
36167503 10.1021/acs.jmedchem.2c00793 Melanocortin receptor 3 2
36167503 10.1021/acs.jmedchem.2c00793 Melanocortin receptor 4 2
36167503 10.1021/acs.jmedchem.2c00793 Melanocortin receptor 5 1

Data from ChEMBL 36 via Core Engine