Compound Detail
CHEMBL5190939
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Basic Information
| ChEMBL ID | CHEMBL5190939 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YKUZPPLSIAFQNK-CMDGGOBGSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
2.49
ALogP
3
HBA
1
HBD
58.6
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| B16-F10 CHEMBL612656 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
| HCT-116 CHEMBL394 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
| NCI-H460 CHEMBL396 | IC50 | 6.34 | 6.34 | 460.0 | 1 |
| HeLa 229 CHEMBL4483246 | IC50 | 5.54 | 5.54 | 2890.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.81 | 4.81 | 15330.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| B16-F10 | IC50 | = | 58.0 | nM | 7.24 | Antiproliferative activity against mouse B16-F10 cells after 72 hrs by MTT assay | 34998058 |
| HCT-116 | IC50 | = | 270.0 | nM | 6.57 | Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay | 34998058 |
| NCI-H460 | IC50 | = | 460.0 | nM | 6.34 | Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assa... | 34998058 |
| HeLa 229 | IC50 | = | 2890.0 | nM | 5.54 | Antiproliferative activity against human HeLa 229 cells after 72 hrs by MTT assa... | 34998058 |
| Fibroblast growth factor receptor 1 | IC50 | = | 15330.0 | nM | 4.81 | Inhibition of FGFR1 (unknown origin) using ULight-JAK-1 (Tyr1023) peptide as sub... | 34998058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34998058 | 10.1016/j.ejmech.2021.114085 | Fibroblast growth factor receptor 1 | 2 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Fibroblast growth factor receptor 2 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Fibroblast growth factor receptor 3 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Platelet-derived growth factor receptor beta | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Epidermal growth factor receptor | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | HeLa 229 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | NCI-H460 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | HCT-116 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | B16-F10 | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | L02 | 1 |
Data from ChEMBL 36 via Core Engine