Compound Detail

CHEMBL5191309

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CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5191309
Phase	Preclinical
Structure Type	MOL
InChI Key	ZKFHMXVIVJCDFY-KHKKPXNASA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

2135.4

MW (Da)

Drug Information

Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C96H127N37O17S2
MW	2135.45

Activity Summary

EC50 4 meas. best 10.35

Ki 3 meas. best 9.14

IC50 1 meas. best 7.38

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Melanocyte-stimulating hormone receptor CHEMBL3795	EC50	10.35	10.35	0.0	1
Melanocortin receptor 3 CHEMBL4644	EC50	9.74	9.74	0.2	1
Melanocyte-stimulating hormone receptor CHEMBL3795	Ki	9.14	9.14	0.7	1
Melanocortin receptor 4 CHEMBL259	EC50	8.75	8.75	1.8	1
Melanocortin receptor 3 CHEMBL4644	Ki	7.96	7.96	11.0	1
Melanocortin receptor 4 CHEMBL259	Ki	7.47	7.47	33.9	1
Melanocortin receptor 5 CHEMBL4608	IC50	7.38	7.38	41.7	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Melanocyte-stimulating hormone receptor	EC50	=	0.04467	nM	10.35	Agonist activity at human MC1R expressed in HEK2936E cells assessed as cAMP prod...	36167503
Melanocortin receptor 3	EC50	=	0.182	nM	9.74	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP prod...	36167503
Melanocyte-stimulating hormone receptor	Ki	=	0.7244	nM	9.14	Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell ...	36167503
Melanocortin receptor 4	EC50	=	1.778	nM	8.75	Antagonist activity at human MC4R expressed in HEK2936E cells assessed as cAMP p...	36167503
Melanocortin receptor 3	Ki	=	10.96	nM	7.96	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell ...	36167503
Melanocortin receptor 4	Ki	=	33.88	nM	7.47	Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell ...	36167503
Melanocortin receptor 5	IC50	=	41.69	nM	7.38	Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP prod...	36167503

Literature References

PubMed	DOI	Target Context	# Activities
36167503	10.1021/acs.jmedchem.2c00793	Unchecked	4
36167503	10.1021/acs.jmedchem.2c00793	Melanocyte-stimulating hormone receptor	3
36167503	10.1021/acs.jmedchem.2c00793	Melanocortin receptor 3	2
36167503	10.1021/acs.jmedchem.2c00793	Melanocortin receptor 4	2
36167503	10.1021/acs.jmedchem.2c00793	Melanocortin receptor 5	1

Data from ChEMBL 36 via Core Engine