Compound Detail
CHEMBL5200857
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COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](CN)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F
Basic Information
| ChEMBL ID | CHEMBL5200857 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FTIGDJCVLXFSBP-LJQIRTBHSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
620.5
MW (Da)
6.37
ALogP
5
HBA
4
HBD
113.7
PSA (Ų)
0.23
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.19
IC50 1 meas. best 6.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 CHEMBL5023 | Ki | 8.19 | 8.105 | 6.5 | 2 |
| HCT-116 CHEMBL394 | IC50 | 6.2 | 6.2 | 631.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.0 | 5.0 | 9932.0 | 1 |
| Protein Mdm4 CHEMBL1255126 | Ki | 4.88 | 4.88 | 13300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | Ki | = | 6.5 | nM | 8.19 | Displacement of 5-FAM labeled PDI peptide from MDM2 (1 to 118 residues) (unknown... | 35420431 |
| E3 ubiquitin-protein ligase Mdm2 | Ki | = | 9.5 | nM | 8.02 | Inhibition of MDM2 (1 to 118 residues)/p53 (unknown origin) interaction expresse... | 38062557 |
| HCT-116 | IC50 | = | 631.0 | nM | 6.2 | Cytotoxicity against human HCT-116 cells expressing wild type p53 and MDM2 asses... | 35420431 |
| Unchecked | Ki | = | 9932.0 | nM | 5.0 | Displacement of 5-FAM labeled PDI peptide from MDM4 C17S mutant (14 to 111 resid... | 35420431 |
| Protein Mdm4 | Ki | = | 13300.0 | nM | 4.88 | Inhibition of MDM4 (14 to 111 residues)/p53 (unknown origin) interaction express... | 38062557 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35420431 | 10.1021/acs.jmedchem.2c00095 | HCT-116 | 1 |
| 35420431 | 10.1021/acs.jmedchem.2c00095 | Unchecked | 1 |
| 35420431 | 10.1021/acs.jmedchem.2c00095 | E3 ubiquitin-protein ligase Mdm2 | 1 |
| 38062557 | 10.1021/acs.jmedchem.3c01815 | E3 ubiquitin-protein ligase Mdm2 | 1 |
| 38062557 | 10.1021/acs.jmedchem.3c01815 | Protein Mdm4 | 1 |
Data from ChEMBL 36 via Core Engine