Compound Detail
CHEMBL5266785
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C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(Oc5ccccc5)c(OC)c4)nn32)CC1
Basic Information
| ChEMBL ID | CHEMBL5266785 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HEFUQOMXBZIABJ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
531.6
MW (Da)
4.24
ALogP
8
HBA
2
HBD
120.9
PSA (Ų)
0.42
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 8.12 | 8.12 | 7.6 | 1 |
| Tyrosine-protein kinase Tec CHEMBL4246 | IC50 | 7.23 | 7.23 | 59.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.33 | 5.33 | 4713.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 7.6 | nM | 8.12 | Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) ... | 36912866 |
| Tyrosine-protein kinase Tec | IC50 | = | 59.0 | nM | 7.23 | Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate ... | 36912866 |
| Epidermal growth factor receptor | IC50 | = | 4713.0 | nM | 5.33 | Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate... | 36912866 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36912866 | 10.1021/acs.jmedchem.2c01938 | Unchecked | 2 |
| 36912866 | 10.1021/acs.jmedchem.2c01938 | Tyrosine-protein kinase BTK | 1 |
| 36912866 | 10.1021/acs.jmedchem.2c01938 | Epidermal growth factor receptor | 1 |
| 36912866 | 10.1021/acs.jmedchem.2c01938 | Tyrosine-protein kinase Tec | 1 |
Data from ChEMBL 36 via Core Engine