Compound Detail
CHEMBL5270915
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Basic Information
| ChEMBL ID | CHEMBL5270915 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OUHGHFXEMHKVJE-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
402.9
MW (Da)
2.89
ALogP
4
HBA
2
HBD
64.0
PSA (Ų)
0.81
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.39
Ki 3 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL2858 | Ki | 9.7 | 9.7 | 0.2 | 1 |
| Mu-type opioid receptor CHEMBL233 | EC50 | 8.39 | 8.39 | 4.1 | 1 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 7.71 | 7.71 | 19.7 | 1 |
| Delta-type opioid receptor CHEMBL236 | Ki | 7.27 | 7.27 | 54.2 | 1 |
| Kappa-type opioid receptor CHEMBL237 | EC50 | 6.46 | 6.46 | 342.8 | 1 |
| Delta-type opioid receptor CHEMBL236 | EC50 | 5.51 | 5.51 | 3111.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 0.2 | nM | 9.7 | Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubat... | 34152138 |
| Mu-type opioid receptor | EC50 | = | 4.1 | nM | 8.39 | Agonist activity at MOR (unknown origin) expressed in CHO cell membranes assesse... | 34152138 |
| Kappa-type opioid receptor | Ki | = | 19.7 | nM | 7.71 | Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incuba... | 34152138 |
| Delta-type opioid receptor | Ki | = | 54.2 | nM | 7.27 | Displacement of [3H]-DPDPE from human DOR expressed in CHO cell membranes measur... | 34152138 |
| Kappa-type opioid receptor | EC50 | = | 342.8 | nM | 6.46 | Agonist activity at KOR (unknown origin) expressed in CHO cell membranes assesse... | 34152138 |
| Delta-type opioid receptor | EC50 | = | 3111.0 | nM | 5.51 | Agonist activity at DOR (unknown origin) expressed in CHO cell membranes assesse... | 34152138 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34152138 | 10.1021/acs.jmedchem.1c00722 | Mu-type opioid receptor | 3 |
| 34152138 | 10.1021/acs.jmedchem.1c00722 | Delta-type opioid receptor | 3 |
| 34152138 | 10.1021/acs.jmedchem.1c00722 | Kappa-type opioid receptor | 3 |
| 34152138 | 10.1021/acs.jmedchem.1c00722 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine