Compound Detail
CHEMBL5283716
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Basic Information
| ChEMBL ID | CHEMBL5283716 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JULROCUWKLNBSN-IMJSIDKUSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
334.1
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| A-375 CHEMBL613859 | IC50 | 5.44 | 5.44 | 3600.0 | 1 |
| CNE-2 CHEMBL4296409 | IC50 | 5.25 | 5.25 | 5600.0 | 1 |
| SW-620 CHEMBL612262 | IC50 | 5.14 | 5.14 | 7300.0 | 1 |
| HL-60 CHEMBL383 | IC50 | 4.46 | 4.46 | 34500.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.19 | 4.19 | 65000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| A-375 | IC50 | = | 3600.0 | nM | 5.44 | Anticancer activity against human A-375 cells assessed as cell growth inhibition... | 34217061 |
| CNE-2 | IC50 | = | 5600.0 | nM | 5.25 | Anticancer activity against human CNE-2 cells assessed as cell growth inhibition... | 34217061 |
| SW-620 | IC50 | = | 7300.0 | nM | 5.14 | Anticancer activity against human SW620 cells assessed as cell growth inhibition... | 34217061 |
| HL-60 | IC50 | = | 34500.0 | nM | 4.46 | Anticancer activity against human HL-60 cells assessed as cell growth inhibition... | 34217061 |
| Plasmodium falciparum | IC50 | = | 65000.0 | nM | 4.19 | Antibacterial activity against Plasmodium falciparum K-1 assessed as bacterial g... | 34217061 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34217061 | 10.1016/j.ejmech.2021.113621 | A-375 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | CNE-2 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | HL-60 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | SW-620 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine