Compound Detail
CHEMBL5284927
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Basic Information
| ChEMBL ID | CHEMBL5284927 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JQMCPEBDJPMQGI-OAHLLOKOSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
411.9
MW (Da)
4.00
ALogP
5
HBA
1
HBD
73.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| fMet-Leu-Phe receptor CHEMBL3359 | EC50 | 6.1 | 5.75 | 794.3 | 2 |
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 5.9 | 5.9 | 1258.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| fMet-Leu-Phe receptor | EC50 | = | 794.33 | nM | 6.1 | Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cell... | 33486199 |
| N-formyl peptide receptor 2 | EC50 | = | 1258.93 | nM | 5.9 | Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cell... | 33486199 |
| fMet-Leu-Phe receptor | EC50 | = | 3981.07 | nM | 5.4 | Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cell... | 33486199 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33486199 | 10.1016/j.ejmech.2021.113167 | fMet-Leu-Phe receptor | 4 |
| 33486199 | 10.1016/j.ejmech.2021.113167 | N-formyl peptide receptor 2 | 4 |
Data from ChEMBL 36 via Core Engine