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Compound Detail

CHEMBL540577

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CC(C)CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl

Basic Information

ChEMBL ID CHEMBL540577
Phase Preclinical
Structure Type MOL
InChI Key MMOUCXURXGTLHC-PKLMIRHRSA-N
Parent Compound CHEMBL1190302
Active Moiety CHEMBL1190302
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

309.4
MW (Da)
3.88
ALogP
3
HBA
2
HBD
43.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24ClNO2
MW 345.87
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.85

Activity Summary

Ki 2 meas. best 6.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Dopamine receptor
CHEMBL2093868
Ki 6.44 6.44 365.0 1
D(2) dopamine receptor
CHEMBL339
Ki 6.31 6.31 490.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2136919 10.1021/jm00163a007 D(1A) dopamine receptor 1
2136919 10.1021/jm00163a007 D(2) dopamine receptor 1
2136919 10.1021/jm00163a007 Dopamine receptor 1
2136919 10.1021/jm00163a007 Dopamine D1 and D2 receptor 1
2136919 10.1021/jm00163a007 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine