Assay Detail
Functional
CHEMBL675879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity was tested in vitro against Dopamine receptor from rat brain membranes with [3H]ADT-6,7-dihydroxy-2-aminotetralin]
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.02 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544618 | — | — | 1 | 9.64 |
| CHEMBL538542 | — | — | 1 | 8.82 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | 4.0 | 1 | 8.43 |
| CHEMBL542493 | — | — | 1 | 8.38 |
| CHEMBL541862 | — | — | 1 | 8.01 |
| CHEMBL553060 | — | — | 1 | 7.89 |
| CHEMBL541867 | — | — | 1 | 7.87 |
| CHEMBL555279 | — | — | 1 | 6.70 |
| CHEMBL540577 | — | — | 1 | 6.44 |
| CHEMBL555049 | — | — | 1 | - |
| CHEMBL558417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544618 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL538542 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL542493 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL541862 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL553060 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL541867 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL555279 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL540577 | — | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL555049 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL558417 | — | Ki | > | 100000.0 | nM | - |