Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL553060

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cl.OCCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3

Basic Information

ChEMBL ID CHEMBL553060
Phase Preclinical
Structure Type MOL
InChI Key KTPLTHGGUDZSTN-PFEQFJNWSA-N
Parent Compound CHEMBL286787
Active Moiety CHEMBL286787
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

297.4
MW (Da)
2.21
ALogP
4
HBA
3
HBD
63.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H20ClNO3
MW 333.82
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 1.13

Activity Summary

Ki 2 meas. best 7.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Dopamine receptor
CHEMBL2093868
Ki 7.89 7.89 12.9 1
D(2) dopamine receptor
CHEMBL339
Ki 5.84 5.84 1460.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2136919 10.1021/jm00163a007 D(1A) dopamine receptor 1
2136919 10.1021/jm00163a007 D(2) dopamine receptor 1
2136919 10.1021/jm00163a007 Dopamine receptor 1
2136919 10.1021/jm00163a007 Dopamine D1 and D2 receptor 1
2136919 10.1021/jm00163a007 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine