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Compound Detail

CHEMBL541867

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Cl.Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3

Basic Information

ChEMBL ID CHEMBL541867
Phase Preclinical
Structure Type MOL
InChI Key FBMBNGLPIIIJDV-PKLMIRHRSA-N
Parent Compound CHEMBL1190928
Active Moiety CHEMBL1190928
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

307.4
MW (Da)
3.63
ALogP
3
HBA
2
HBD
43.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H22ClNO2
MW 343.85
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.89

Activity Summary

Ki 3 meas. best 9.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
Ki 9.37 9.37 0.4 1
Dopamine receptor
CHEMBL2093868
Ki 7.87 7.87 13.5 1
D(1A) dopamine receptor
CHEMBL265
Ki 6.14 6.14 730.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2136919 10.1021/jm00163a007 D(1A) dopamine receptor 1
2136919 10.1021/jm00163a007 D(2) dopamine receptor 1
2136919 10.1021/jm00163a007 Dopamine receptor 1
2136919 10.1021/jm00163a007 Dopamine D1 and D2 receptor 1
2136919 10.1021/jm00163a007 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine