Assay Detail
Binding
CHEMBL670436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.46 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544618 | — | — | 1 | 6.91 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | 4.0 | 1 | 6.62 |
| CHEMBL538542 | — | — | 1 | 6.47 |
| CHEMBL541862 | — | — | 1 | 6.41 |
| CHEMBL542493 | — | — | 1 | 6.21 |
| CHEMBL541867 | — | — | 1 | 6.14 |
| CHEMBL555049 | — | — | 1 | - |
| CHEMBL553060 | — | — | 1 | - |
| CHEMBL558417 | — | — | 1 | - |
| CHEMBL555279 | — | — | 1 | - |
| CHEMBL540577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544618 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL538542 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL541862 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL542493 | — | Ki | = | 615.0 | nM | 6.21 |
| CHEMBL541867 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL555049 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL553060 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL558417 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL555279 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL540577 | — | Ki | > | 10000.0 | nM | - |