Compound Detail
CHEMBL5563847
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Basic Information
| ChEMBL ID | CHEMBL5563847 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NYHIXPIBUNDOQS-CYBMUJFWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
400.3
MW (Da)
3.66
ALogP
3
HBA
1
HBD
61.8
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
| fMet-Leu-Phe receptor CHEMBL3359 | EC50 | 4.62 | 4.62 | 24000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | EC50 | = | 10000.0 | nM | 5.0 | Agonist activity at human FPR2 expressed in HL-60 cells assessed as increase in ... | 38199163 |
| fMet-Leu-Phe receptor | EC50 | = | 24000.0 | nM | 4.62 | Agonist activity at human FPR1 expressed in HL-60 cells assessed as increase in ... | 38199163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38199163 | 10.1016/j.ejmech.2023.115989 | fMet-Leu-Phe receptor | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | N-formyl peptide receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine