Compound Detail
CHEMBL5591364
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Basic Information
| ChEMBL ID | CHEMBL5591364 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KYJMGZFTFUOCOO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
460.9
MW (Da)
4.38
ALogP
5
HBA
3
HBD
98.5
PSA (Ų)
0.47
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.51 | 7.51 | 31.0 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 6.87 | 6.87 | 135.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 31.0 | nM | 7.51 | Inhibition of PDGFRbeta (unknown origin) by DiscoverX KINOMEscan assay | 37683364 |
| Platelet-derived growth factor receptor alpha | IC50 | = | 135.0 | nM | 6.87 | Inhibition of wild type human PDGFRalpha transfected with CHO cells by ADP-Glo a... | 37683364 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37683364 | 10.1016/j.ejmech.2023.115762 | Platelet-derived growth factor receptor alpha | 1 |
| 37683364 | 10.1016/j.ejmech.2023.115762 | Platelet-derived growth factor receptor beta | 1 |
Data from ChEMBL 36 via Core Engine