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Compound Detail

CHEMBL569275

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OC[C@H]1O[C@@H](n2cnc3c(NC4CCC4)ncnc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL569275
Phase Preclinical
Structure Type MOL
InChI Key LDCLWBBQUVOXBH-IDTAVKCVSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

321.3
MW (Da)
-0.60
ALogP
9
HBA
4
HBD
125.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H19N5O4
MW 321.34
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.70

Activity Summary

Ki 4 meas. best 9.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 9.11 8.76 0.8 2
Adenosine A2 receptor
CHEMBL2094117
Ki 6.58 6.58 263.0 1
Adenosine receptor A2a
CHEMBL302
Ki 6.38 6.38 420.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2999397 10.1021/jm00149a016 Alpha-1A adrenergic receptor 1
2999397 10.1021/jm00149a016 ADMET 1
10649980 10.1021/jm9911231 Adenosine receptor A1 1
10649980 10.1021/jm9911231 Adenosine receptor A2a 1
10649980 10.1021/jm9911231 Adenosine receptors; A1 & A2a 1
2995663 10.1021/jm00148a001 Adenosine receptor A1 1
2995663 10.1021/jm00148a001 Adenosine A2 receptor 1
2995663 10.1021/jm00148a001 No relevant target 1
2995663 10.1021/jm00148a001 Adenosine receptors; A1 & A2 1
19731917 10.1021/jm9006356 Unchecked 1

Data from ChEMBL 36 via Core Engine