Compound Detail
CHEMBL572581
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C[C@@]1(C(=O)Nc2cccnc2)CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1
Basic Information
| ChEMBL ID | CHEMBL572581 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGGGQYILVSQJDN-QHCPKHFHSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
3.47
ALogP
8
HBA
3
HBD
116.1
PSA (Ų)
0.42
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
| Cyclin-dependent kinase 2/cyclin E CHEMBL2094126 | IC50 | 5.84 | 5.84 | 1432.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 6.0 | nM | 8.22 | Inhibition of IGF1R after 60 mins by fluorescence electrophoresis | 19778024 |
| NON-PROTEIN TARGET | IC50 | = | 24.0 | nM | 7.62 | Antiproliferative activity against mouse Sal cells overexpressing IGF1R assessed... | 19778024 |
| Cyclin-dependent kinase 2/cyclin E | IC50 | = | 1432.0 | nM | 5.84 | Inhibition of CDK2/Cyclin E after 60 mins by fluorescence electrophoresis | 19778024 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19778024 | 10.1021/jm900786r | NON-PROTEIN TARGET | 3 |
| 19778024 | 10.1021/jm900786r | Insulin-like growth factor 1 receptor | 1 |
| 19778024 | 10.1021/jm900786r | Cyclin-dependent kinase 2/cyclin E | 1 |
| 19778024 | 10.1021/jm900786r | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine