Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5834528

INX-315
Phase I
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Phase I
NS(=O)(=O)c1ccc(Nc2ncc3cc4n(c3n2)C2(CCCCC2)C(=O)NN4)cc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5834528
Name INX-315
Phase Phase I
Structure Type MOL
InChI Key KGJVKYSVVOQPDL-UHFFFAOYSA-N

Known Names

Inx-315 INX315
9
Targets
9
Activities
1
Assay Types
0
PK Parameters
0
Publications
2
Known Names

Molecular Properties

427.5
MW (Da)
1.94
ALogP
8
HBA
4
HBD
144.0
PSA (Ų)
0.50
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Chemical Probe

Extended Properties

Molecular Formula C19H21N7O3S
MW 427.49
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -1.02

Activity Summary

IC50 9 meas. best 9.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cyclin-dependent kinase 2/cyclin E1
CHEMBL1907605
 IC50 9.25 9.25 0.6 1
CDK2/Cyclin A2
CHEMBL3038469
 IC50 8.6 8.6 2.5 1
CDK3/Cyclin E
CHEMBL3038471
 IC50 8.0 8.0 9.9 1
Cyclin-dependent kinase 5/CDK5 activator 1
CHEMBL1907600
 IC50 7.85 7.85 14.0 1
Cyclin-dependent kinase 5 activator 1
CHEMBL2783
 IC50 7.77 7.77 17.0 1
Cyclin-dependent kinase 1
CHEMBL308
 IC50 7.48 7.48 33.0 1
CDK9/cyclin T1
CHEMBL2111389
 IC50 7.21 7.21 62.0 1
Cyclin-dependent kinase 4/cyclin D1
CHEMBL1907601
 IC50 6.89 6.89 130.0 1
CDK6/cyclin D3
CHEMBL2111448
 IC50 6.46 6.46 350.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cyclin-dependent kinase 2/cyclin E1 IC50 = 0.56 nM 9.25 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
CDK2/Cyclin A2 IC50 = 2.5 nM 8.6 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
CDK3/Cyclin E IC50 = 9.9 nM 8.0 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
Cyclin-dependent kinase 5/CDK5 activator 1 IC50 = 14.0 nM 7.85 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
Cyclin-dependent kinase 5 activator 1 IC50 = 17.0 nM 7.77 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
Cyclin-dependent kinase 1 IC50 = 33.0 nM 7.48 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
CDK9/cyclin T1 IC50 = 62.0 nM 7.21 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
Cyclin-dependent kinase 4/cyclin D1 IC50 = 130.0 nM 6.89 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -
CDK6/cyclin D3 IC50 = 350.0 nM 6.46 CDK Inhibition In Vitro Assay: Selected compounds disclosed herein were tested i... -

Data from ChEMBL 36 via Core Engine