Compound Detail
CHEMBL5983777
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Basic Information
| ChEMBL ID | CHEMBL5983777 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | POPIUCWMQJYOGO-AWEZNQCLSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
440.9
MW (Da)
4.82
ALogP
5
HBA
3
HBD
87.1
PSA (Ų)
0.49
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Activin receptor type-1B CHEMBL5310 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 7.79 | 7.79 | 16.2 | 1 |
| Activin receptor type-1-like CHEMBL5311 | IC50 | 5.18 | 5.18 | 6570.0 | 1 |
| Activin receptor type-1 CHEMBL5903 | IC50 | 4.96 | 4.96 | 10900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Activin receptor type-1B | IC50 | = | 13.0 | nM | 7.89 | In Vitro Kinase Assay: Compound of the invention were screened in an in vitro ki... | - |
| TGF-beta receptor type-1 | IC50 | = | 16.2 | nM | 7.79 | In Vitro Kinase Assay: Compound of the invention were screened in an in vitro ki... | - |
| Activin receptor type-1-like | IC50 | = | 6570.0 | nM | 5.18 | In Vitro Kinase Assay: Compound of the invention were screened in an in vitro ki... | - |
| Activin receptor type-1 | IC50 | = | 10900.0 | nM | 4.96 | In Vitro Kinase Assay: Compound of the invention were screened in an in vitro ki... | - |
Data from ChEMBL 36 via Core Engine