Compound Detail
CHEMBL70303
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COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1
Basic Information
| ChEMBL ID | CHEMBL70303 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YDIGUOCUKLHGNZ-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
630.6
MW (Da)
4.26
ALogP
13
HBA
2
HBD
189.5
PSA (Ų)
0.19
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
Kd 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL4566 | Kd | 9.0 | 9.0 | 1.0 | 1 |
| Endothelin-1 receptor CHEMBL252 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Endothelin receptor type B CHEMBL1785 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | Kd | = | 1.0 | nM | 9.0 | Evaluation for functional inhibitory potency prevention of ET-1 induced constric... | - |
| Endothelin-1 receptor | IC50 | = | 4.0 | nM | 8.4 | Receptor binding affinity was determined against [125I]ET1 with recombinant huma... | - |
| Endothelin receptor type B | IC50 | = | 170.0 | nM | 6.77 | Receptor binding affinity was determined against [125I]ET1 with membranes prepar... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00400-9 | Endothelin-1 receptor | 2 |
| - | 10.1016/S0960-894X(97)00400-9 | Endothelin receptor type B | 1 |
Data from ChEMBL 36 via Core Engine