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Compound Detail

CHEMBL7186

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Oc1ccc2c(c1O)CCCC2C1=NCCN1

Basic Information

ChEMBL ID CHEMBL7186
Phase Preclinical
Structure Type MOL
InChI Key LYRNYBCBYWDTIF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

232.3
MW (Da)
1.52
ALogP
4
HBA
3
HBD
64.8
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H16N2O2
MW 232.28
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness 1.02

Activity Summary

Ki 2 meas. best 8.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 8.19 8.19 6.5 1
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 6.4 6.4 400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2884313 10.1021/jm00389a009 Unchecked 4
2884313 10.1021/jm00389a009 Adrenergic receptor alpha-1 3
2884313 10.1021/jm00389a009 Adrenergic receptor alpha-2 3
3016266 10.1021/jm00158a016 Adrenergic receptor alpha-1 2
3016266 10.1021/jm00158a016 Unchecked 2
3016266 10.1021/jm00158a016 Adrenergic receptor alpha-2 2

Data from ChEMBL 36 via Core Engine