Assay Detail
Binding
CHEMBL649436
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Binding affinity for alpha-1 adrenergic receptor in rat liver using [3H]prazosin.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally defined adrenergic agents. 5. Resolution, absolute configuration, and pharmacological characterization of the enantiomers of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline: a potent agonist at alpha-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.29 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.41 |
| CHEMBL7186 | — | — | 1 | 6.40 |
| CHEMBL7707 | — | — | 1 | 6.28 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 6.28 |
| CHEMBL7169 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL7186 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL7707 | — | Ki | = | 523.0 | nM | 6.28 |
| CHEMBL134 | CLONIDINE | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL7169 | — | Ki | = | 817.0 | nM | 6.09 |