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Compound Detail

CHEMBL75217

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CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1

Basic Information

ChEMBL ID CHEMBL75217
Phase Preclinical
Structure Type MOL
InChI Key OPZQMZXXMIXWON-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

402.4
MW (Da)
5.05
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.33
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H29Cl2NO3
MW 402.36
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness -0.84

Activity Summary

Ki 4 meas. best 7.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 7.7 7.7 20.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 7.66 7.66 22.0 1
Sigma non-opioid intracellular receptor 1
CHEMBL3602
Ki 7.66 7.66 22.0 1
Sigma 2 receptor
CHEMBL613288
Ki 6.18 6.18 667.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8057277 10.1021/jm00041a006 Sigma non-opioid intracellular receptor 1 2
8057277 10.1021/jm00041a006 Sigma 2 receptor 1
8057277 10.1021/jm00041a006 Glutamate NMDA receptor 1
8057277 10.1021/jm00041a006 Muscarinic acetylcholine receptor M1 1
8057277 10.1021/jm00041a006 Muscarinic acetylcholine receptor M2 1
8057277 10.1021/jm00041a006 Unchecked 1

Data from ChEMBL 36 via Core Engine