Assay Detail
Binding
CHEMBL745744
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Binding affinity towards muscarinic m1 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.69 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.70 |
| CHEMBL75217 | — | — | 1 | 7.70 |
| CHEMBL73017 | — | — | 1 | 7.20 |
| CHEMBL72219 | — | — | 1 | 7.12 |
| CHEMBL73234 | CARBETAPENTANE | 4.0 | 1 | 7.12 |
| CHEMBL74736 | — | — | 1 | 6.87 |
| CHEMBL73501 | — | — | 1 | 6.24 |
| CHEMBL451542 | — | — | 1 | 6.07 |
| CHEMBL72506 | — | — | 1 | 6.04 |
| CHEMBL74305 | — | — | 1 | 5.98 |
| CHEMBL308707 | — | — | 1 | 5.77 |
| CHEMBL307628 | — | — | 1 | 5.51 |
| CHEMBL309172 | — | — | 1 | - |
| CHEMBL307668 | — | — | 1 | - |
| CHEMBL73762 | — | — | 1 | - |
| CHEMBL440686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL75217 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL73017 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL72219 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL73234 | CARBETAPENTANE | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL74736 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL73501 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL451542 | — | Ki | = | 843.0 | nM | 6.07 |
| CHEMBL72506 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL74305 | — | Ki | = | 1058.0 | nM | 5.98 |
| CHEMBL308707 | — | Ki | = | 1697.0 | nM | 5.77 |
| CHEMBL307628 | — | Ki | = | 3110.0 | nM | 5.51 |
| CHEMBL309172 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL307668 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL73762 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL440686 | — | Ki | > | 10000.0 | nM | - |