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Target Snapshot

CHEMBL2048 Target Snapshot

Fibrinogen beta chain · SINGLE PROTEIN · Homo sapiens

37Compounds
2Assays
0Approved Drugs
74.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P02675. Use UniProt P02675 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02675 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fibrinogen beta chain as ChEMBL target CHEMBL2048, mapped to UniProt P02675. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fibrinogen beta chain
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2048
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P02675
Fibrinogen beta chain
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fibrinogen beta chain is the right protein anchor across sources, using UniProt P02675 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFibrinogen beta chain
UniProt AccessionP02675
Component TypeProtein
Sequence Length491 aa

Fibrinogen beta chain

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Fibrinogen beta chain, mapped to UniProt P02675. Sequence length is 491 aa.

Mapped IDP02675
Review nameFibrinogen beta chain
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5074.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1334670 5.3 IC50 4965.0 Preclinical
CHEMBL600008 5.3 IC50 4979.0 Preclinical
CHEMBL1451725 5.07 IC50 8514.0 Preclinical
CHEMBL1384064 5.05 IC50 8920.0 Preclinical
CHEMBL1708493 5.04 IC50 9103.0 Preclinical
CHEMBL1479103 5.03 IC50 9328.0 Preclinical
CHEMBL1882477 5.03 IC50 9237.0 Preclinical
CHEMBL1404361 5.0 IC50 10117.0 Preclinical
CHEMBL1561204 4.99 IC50 10247.0 Preclinical
CHEMBL1324024 4.97 IC50 10587.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
25
Tested Compounds
1
Assay Types
Binding — 2 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 25 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine