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Compound Detail

CHEMBL1324024

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Cc1cc2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCOCC4)cc3)ccc2n1C

Basic Information

ChEMBL ID CHEMBL1324024
Phase Preclinical
Structure Type MOL
InChI Key KENHJKZIEBPMNF-UHFFFAOYSA-N
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

427.5
MW (Da)
2.44
ALogP
5
HBA
1
HBD
80.6
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25N3O4S
MW 427.53
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -1.99

Activity Summary

EC50 3 meas. best 5.17
IC50 2 meas. best 4.97

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 1
CHEMBL2095162
EC50 5.17 5.17 6777.0 1
Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 2
CHEMBL2095163
EC50 5.17 5.17 6712.0 1
Fibrinogen beta chain
CHEMBL2048
IC50 4.97 4.97 10587.0 1
Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 3
CHEMBL2095161
EC50 4.8 4.8 15720.0 1
Polyadenylate-binding protein 1
CHEMBL1293286
IC50 4.3 4.3 49600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine