Compound Detail
CHEMBL1451725
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1451725 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MXACPJKCPLBEQM-UHFFFAOYSA-N |
5
Targets
7
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
3.83
ALogP
5
HBA
2
HBD
79.3
PSA (Ų)
0.71
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 4.98
IC50 1 meas. best 5.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibrinogen beta chain CHEMBL2048 | IC50 | 5.07 | 5.07 | 8514.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 4.98 | 4.6567 | 10423.0 | 3 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.96 | 4.96 | 10987.0 | 1 |
| Troponin, cardiac muscle CHEMBL2095202 | EC50 | 4.73 | 4.73 | 18755.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.12 | 4.12 | 76110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibrinogen beta chain | IC50 | = | 8514.0 | nM | 5.07 | PubChem BioAssay. Fluorescence polarization-based biochemical high throughput do... | - |
| Unchecked | EC50 | = | 10423.0 | nM | 4.98 | PUBCHEM_BIOASSAY: High Throughput Screen to Identify Compounds that Suppress the... | - |
| Zinc finger protein mex-5 | EC50 | = | 10987.0 | nM | 4.96 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Unchecked | EC50 | = | 15351.0 | nM | 4.81 | PUBCHEM_BIOASSAY: High Throughput Screen to Identify Compounds that Suppress the... | - |
| Troponin, cardiac muscle | EC50 | = | 18755.0 | nM | 4.73 | PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response a... | - |
| Unchecked | EC50 | = | 65802.0 | nM | 4.18 | PUBCHEM_BIOASSAY: Counterscreen for activators of the calcium sensitivity of car... | - |
| RNA-binding protein pos-1 | EC50 | = | 76110.0 | nM | 4.12 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Data from ChEMBL 36 via Core Engine