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Compound Detail

CHEMBL1479103

HAEMATOXYLIN
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Oc1cc2c(cc1O)C1c3ccc(O)c(O)c3OCC1(O)C2

Basic Information

ChEMBL ID CHEMBL1479103
Name HAEMATOXYLIN
Phase Preclinical
Structure Type MOL
InChI Key WZUVPPKBWHMQCE-UHFFFAOYSA-N
10
Targets
14
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

302.3
MW (Da)
1.32
ALogP
6
HBA
5
HBD
110.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C16H14O6
MW 302.28
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 2.20

Activity Summary

IC50 9 meas. best 5.46
EC50 5 meas. best 4.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Induced myeloid leukemia cell differentiation protein Mcl-1
CHEMBL4361
IC50 5.46 5.46 3439.3 1
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
CHEMBL1741212
IC50 5.32 4.8133 4740.0 3
Fibrinogen beta chain
CHEMBL2048
IC50 5.03 5.03 9328.0 1
Major prion protein
CHEMBL4869
IC50 4.86 4.86 13956.0 1
Mannose-6-phosphate isomerase
CHEMBL2758
IC50 4.58 4.58 26374.0 1
Endoribonuclease toxin MazF
CHEMBL1795096
EC50 4.52 4.33 30100.0 2
Intestinal-type alkaline phosphatase
CHEMBL5573
EC50 4.3 4.3 50000.0 1
Alkaline phosphatase, germ cell type
CHEMBL3402
EC50 4.22 4.22 60400.0 1
Glucose-6-phosphate 1-dehydrogenase
CHEMBL5347
IC50 4.18 4.18 66500.0 1
Alkaline phosphatase, tissue-nonspecific isozyme
CHEMBL5979
EC50 4.07 4.07 85700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Induced myeloid leukemia cell differentiation protein Mcl-1 IC50 = 3439.26 nM 5.46 PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibito... -
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase IC50 = 4740.0 nM 5.32 PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... -
Fibrinogen beta chain IC50 = 9328.0 nM 5.03 PubChem BioAssay. Fluorescence polarization-based biochemical high throughput do... -
Major prion protein IC50 = 13956.0 nM 4.86 PubChem BioAssay. TRFRET-based cell-based high throughput dose response assay to... -
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase IC50 = 25900.0 nM 4.59 PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point ... -
Mannose-6-phosphate isomerase IC50 = 26374.0 nM 4.58 PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isom... -
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase IC50 = 29500.0 nM 4.53 PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct de... -
Endoribonuclease toxin MazF EC50 = 30100.0 nM 4.52 PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... -
Intestinal-type alkaline phosphatase EC50 = 50000.0 nM 4.3 PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Mouse Intesti... -
Alkaline phosphatase, germ cell type EC50 = 60400.0 nM 4.22 PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Mouse Intesti... -
Glucose-6-phosphate 1-dehydrogenase IC50 = 66500.0 nM 4.18 PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectiv... -
Endoribonuclease toxin MazF EC50 = 72800.0 nM 4.14 PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... -
Alkaline phosphatase, tissue-nonspecific isozyme EC50 = 85700.0 nM 4.07 PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Mouse Intesti... -

Literature References

PubMed DOI Target Context # Activities
34726055 10.1021/acs.jmedchem.1c00981 Pyruvate kinase PKM 1

Data from ChEMBL 36 via Core Engine