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Target Snapshot

CHEMBL6003 Target Snapshot

Testis-specific serine/threonine-protein kinase 1 · SINGLE PROTEIN · Homo sapiens

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1,473Compounds
272Assays
7Approved Drugs
673.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9BXA7. Use UniProt Q9BXA7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9BXA7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Testis-specific serine/threonine-protein kinase 1 as ChEMBL target CHEMBL6003, mapped to UniProt Q9BXA7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Testis-specific serine/threonine-protein kinase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL6003
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9BXA7
Testis-specific serine/threonine-protein kinase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Testis-specific serine/threonine-protein kinase 1 is the right protein anchor across sources, using UniProt Q9BXA7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameTestis-specific serine/threonine-protein kinase 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9BXA7
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTestis-specific serine/threonine-protein kinase 1
UniProt AccessionQ9BXA7
Component TypeProtein
Sequence Length367 aa

Testis-specific serine/threonine-protein kinase 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Testis-specific serine/threonine-protein kinase 1, mapped to UniProt Q9BXA7. Sequence length is 367 aa.

Mapped IDQ9BXA7
Review nameTestis-specific serine/threonine-protein kinase 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
3
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5035.0
KI515.0
KD123.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 10.33 IC50 0.0473 Preclinical
CHEMBL4546504 9.66 IC50 0.217 Preclinical
CHEMBL1971029 8.6 Ki 2.512 Preclinical
CHEMBL3545311 8.36 IC50 4.4 Approved
CHEMBL2001751 8.2 Ki 6.31 Preclinical
CHEMBL1993661 8.1 Ki 7.943 Preclinical
CHEMBL1995813 7.8 Ki 15.85 Preclinical
CHEMBL4465866 7.75 Kd 18.0 Preclinical
CHEMBL4576489 7.72 Kd 19.0 Preclinical
CHEMBL4550702 7.7 IC50 20.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
15
5.5
26
6.0
15
6.5
14
7.0
11
7.5
3
8.0
1
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

BRIGATINIB
CHEMBL3545311
Approved 2017
Properties Compare Identifier
CERITINIB
CHEMBL2403108
Approved 2014
Properties Compare Identifier
Assay Landscape

Assay Landscape

272
Total Assays
61
Tested Compounds
2
Assay Types
Binding — 271 assays, 31 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 201 26 6.2
assay format 57 3 7.6
cell-based format 13 2 7.7
Functional — 1 assays, 61 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 61 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine