Assay Detail
Binding
CHEMBL1211032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosome
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-D-QSAR and docking studies on the neuronal choline transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 5.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1209654 | — | — | 1 | 7.70 |
| CHEMBL1209507 | — | — | 1 | 7.30 |
| CHEMBL1209508 | — | — | 1 | 7.05 |
| CHEMBL1209577 | — | — | 1 | 6.74 |
| CHEMBL1209578 | — | — | 1 | 6.70 |
| CHEMBL1209579 | — | — | 1 | 6.64 |
| CHEMBL1209581 | — | — | 1 | 6.28 |
| CHEMBL1209713 | — | — | 1 | 6.19 |
| CHEMBL282468 | CHOLINE CHLORIDE | 4.0 | 1 | 6.17 |
| CHEMBL1209653 | — | — | 1 | 6.15 |
| CHEMBL1209506 | — | — | 1 | 5.70 |
| CHEMBL1209422 | — | — | 1 | 5.66 |
| CHEMBL1209582 | — | — | 1 | 5.33 |
| CHEMBL1209651 | TETRAMETHYLAMMONIUM | — | 1 | 4.52 |
| CHEMBL34833 | — | — | 1 | 4.49 |
| CHEMBL1209648 | — | — | 1 | 4.40 |
| CHEMBL1135 | DIMETHYLAMINOETHANOL | 2.0 | 1 | 4.25 |
| CHEMBL1209649 | — | — | 1 | 4.14 |
| CHEMBL1209421 | — | — | 1 | 4.12 |
| CHEMBL120433 | DIMETHYLAMINE | — | 1 | - |
| CHEMBL3 | NICOTINE | 4.0 | 1 | - |
| CHEMBL1209423 | — | — | 1 | - |
| CHEMBL1209424 | — | — | 1 | - |
| CHEMBL1209652 | — | — | 1 | - |
| CHEMBL439723 | TRIMETHYLAMMONIUM | — | 1 | - |
| CHEMBL104943 | MONOETHANOLAMINE | 2.0 | 1 | - |
| CHEMBL284348 | DALFAMPRIDINE | 4.0 | 1 | - |
| CHEMBL104083 | — | — | 1 | - |
| CHEMBL276310 | — | — | 1 | - |
| CHEMBL1078612 | TETRABUTYLAMMONIUM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1209654 | — | Ki | = | 20.04 | nM | 7.70 |
| CHEMBL1209507 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1209508 | — | Ki | = | 90.01 | nM | 7.05 |
| CHEMBL1209577 | — | Ki | = | 180.3 | nM | 6.74 |
| CHEMBL1209578 | — | Ki | = | 200.45 | nM | 6.70 |
| CHEMBL1209579 | — | Ki | = | 230.14 | nM | 6.64 |
| CHEMBL1209581 | — | Ki | = | 521.19 | nM | 6.28 |
| CHEMBL1209713 | — | Ki | = | 640.03 | nM | 6.19 |
| CHEMBL282468 | CHOLINE CHLORIDE | Ki | = | 680.77 | nM | 6.17 |
| CHEMBL1209653 | — | Ki | = | 701.46 | nM | 6.15 |
| CHEMBL1209506 | — | Ki | = | 2000.32 | nM | 5.70 |
| CHEMBL1209422 | — | Ki | = | 2202.93 | nM | 5.66 |
| CHEMBL1209582 | — | Ki | = | 4700.02 | nM | 5.33 |
| CHEMBL1209651 | TETRAMETHYLAMMONIUM | Ki | = | 30060.76 | nM | 4.52 |
| CHEMBL34833 | — | Ki | = | 32062.69 | nM | 4.49 |
| CHEMBL1209648 | — | Ki | = | 40086.67 | nM | 4.40 |
| CHEMBL1135 | DIMETHYLAMINOETHANOL | Ki | = | 55718.57 | nM | 4.25 |
| CHEMBL1209649 | — | Ki | = | 72110.75 | nM | 4.14 |
| CHEMBL1209421 | — | Ki | = | 75162.29 | nM | 4.12 |
| CHEMBL9324 | TETRYLAMMONIUM | Ki | = | 260015.96 | nM | - |
| CHEMBL1209505 | — | Ki | = | 340016.51 | nM | - |
| CHEMBL1209504 | — | Ki | = | 270022.53 | nM | - |
| CHEMBL43280 | METHYLAMINE | Ki | = | 35075187.4 | nM | - |
| CHEMBL1209580 | — | Ki | = | 107151.93 | nM | - |
| CHEMBL354077 | AMIFAMPRIDINE | Ki | = | 820351.54 | nM | - |
| CHEMBL1209503 | — | Ki | = | 190107.83 | nM | - |
| CHEMBL1209650 | — | Ki | = | 210377.84 | nM | - |
| CHEMBL1078612 | TETRABUTYLAMMONIUM | Ki | = | 1051961.87 | nM | - |
| CHEMBL276310 | — | Ki | = | 210377.84 | nM | - |
| CHEMBL104083 | — | Ki | = | 3801893.96 | nM | - |
| CHEMBL284348 | DALFAMPRIDINE | Ki | = | 480839.35 | nM | - |
| CHEMBL104943 | MONOETHANOLAMINE | Ki | = | 150003019.05 | nM | - |
| CHEMBL439723 | TRIMETHYLAMMONIUM | Ki | = | 340016.51 | nM | - |
| CHEMBL1209652 | — | Ki | = | 360578.64 | nM | - |
| CHEMBL1209424 | — | Ki | = | 290402.27 | nM | - |
| CHEMBL1209423 | — | Ki | = | 310455.96 | nM | - |
| CHEMBL3 | NICOTINE | Ki | = | 520115.74 | nM | - |
| CHEMBL120433 | DIMETHYLAMINE | Ki | = | 9418895.97 | nM | - |